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Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia Several studies have established an association between ED and BPH-related LUTS where alterations in the NO/cGMP pathway, alterations in RhoA/Rho kinase/endothelin signaling, pelvic atherosclerosis, autonomic adrenergic hyperactivity, inflammatory pathways, sex hormones and psychological factors were the major contributing factors [53,54]

Acanthosis Nigricans Symptoms One main sign of acanthosis nigricans is the thick, velvety, light-brown-to-black patch that often appears in the skin folds in the front or back of your neck, armpit, elbows, knees, belly button, or under your breast

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In parallel, recent studies have demonstrated that asymptomatic carriage is associated with a marked reduction in URT microbiota diversity and an increased abundance of Haemophilus influenzae (Koenen et al., 2023)

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